What Are The Advantages Of Prefilled Syringe Boxes?

This type of prefilled syringe has been increasingly adopted in recent years as it does not require transfer of the drug from a container such as vial to a syringe, which is more convenient and safer for medical practitioners.

This prefilled syringe is generally packaged in a carton after it is set in a plastic tray or a paper inner tray. A paper inner tray has an advantage over a plastic one as it does not have to be separated from the carton in disposal.The inner tray is flat before assembling, so it does not take up space for storage at pharmaceutical companies.The configuration of this inner tray is simplified and has high shock-absorbing effect. It is easy to assemble and will make packaging process efficient.

When a tray and syringe are set in the carton.The packaging has high shock-absorbing effect as the prefilled syringe remains and fixed in the air with very few holding points of the packaging. Besides, it is easy to open the carton and take out the prefilled syringe.

1 Prefilled syringes and injection devices have become widely accepted.

1.Prefilled syringes have gained wide acceptance, driven by various factors including lifecycle benefits

The prefilled syringe or injection device is easy for healthcare professionals to handle.

The risks of spillage, contamination and ampoule cuts are reduced or eliminated. Furthermore, the potential risks of misidentification or dosage error are greatly reduced.

The potential risk of needlestick injury, associated with all methods of injection, is greatly reduced by the addition of a safety needle device to the syringe.  

The availability of such devices enables compliance with current and envisaged legislation.

Self-administration by patients on long-term therapies is practical.

For the pharmacist, requirements for storage, preparation and disposal are simplified.

For the pharmaceutical manufacturer, the prefilled syringe and injection device offer advantages in both marketing and distribution.

2.The development of prefilled syringes and injection devices

For the prefilled syringe and injection device there is no overfilling required, as it is filled with less drug substance per dose than a vial or ampoule, hence leading to significant cost savings.

Prefilled syringes and injection devices are being used increasingly frequently, so that application of liquid pharmaceutical products at the doctor’s surgery, by nursing personnel or by patients at home, can be more simply and reliably handled. In the simplest case, it is necessary only to remove the needle protection prior to injecting the drug. There is no longer any need to break off the heads of ampoules, with the possible ensuing injuries, or for troublesome handling of vials or syringes.

Since the products are distinctly more expensive than other pharmaceuticals, they must be packed as securely as possible. Moreover, often the products have to be transported in a precisely defined temperature environment. Cold chain logistics are needed to ensure that a product is transported at the correct temperature from manufacture through transport, and storage to administration.

Many pharmaceutical companies produce and market a wide range of products worldwide. The different demand in the respective market and product segments therefore requires a highly flexible packaging system which can handle a wide range of different items and, at the same time, provide optimal product protection. It is also essential to guarantee efficient, low-cost packaging of small, medium and large lot sizes.

2 Packaging need to pay attention to the matter requirements

1.The Importance of Correctly Selected Reusable Packaging

All packages must safeguard the product throughout its route from manufacture to final point of use. The package must also convey sufficient information to ensure that the product is used correctly. Each package provides the vital link between manufacturer and consumer; it is an essential component of the product itself.

The prefilled syringe and injection device are examples of a high-value product that must be safeguarded throughout a long shelflife and yet be readily and accurately used whenever required. The proper selection of the package and the attention to its design will promote the benefits of the product in addition to fulfilling these fundamental functions. The syringe or device is not viable without a secondary package.

2.Reusable sealed packaging

The package must enable rapid access to each of the products it contains, and must remain intact until the last of the syringes or devices has been removed, if that last product is to be safeguarded. The printing of the package will clearly present essential product information. Further features may confirm that the syringe or device is untouched until required for use.

A re-closable package can be retained for subsequent use without difficulty. If the package contains a course of treatment for a single patient, features to assist dosage compliance are appropriate. If the contents are to be used over an extended period, opening features that release only one product at a time can assist the user.

3 Cardboard partition packaging

This space saving is achieved thanks to partition packaging special design concept. Since the whole box is made of flat cardboard, customised partitions, specially adapted to the products, can easily be glued inside the box. The product is placed crosswise in relation to these flutes. In the case of a syringe pack, for example, the syringes are inserted in front of and behind the barrel of a syringe in such a way that the product itself virtually “floats” and is connected to the actual box only by the two flutes. In this way multiple products can be packaged close to each other without touching.

Since the products do not touch the base or the lid of the box, they are highly impact-resistant and the firmly anchored products cannot break even if they are dropped onto the floor. This flute concept is highly versatile, so the layout within a box can easily be adapted to individual customers’ needs. In so-called combi packs, not only the syringes but also the accompanying vials and accessories, such as needles, filters and the like can be inserted at fixed points.

“A reduction in pack volume of 50% cut the expensive cold-chain shipping and storage costs in half…”

4 Volume savings of packaging

folding boxes are pure monomaterial packaging,the folding box is made from 100% cardboard material. This distinguishes it from other conventional Top-Load packs. For customers in the pharmaceutical industry, this means that by using only one packaging material the space required and the transport costs can be significantly reduced. Volume savings of 25% to 50% compared with traditional blister packs. These figures are important in that many of these highly sensitive drugs are cold-chain products. In other words, they must be cooled continuously from production until they are used by the patient. The less space these products take up the better. This includes space in the refrigerator in which general practitioners keeps their sensitive vaccines, for example.

A reduction in pack volume of 50% cut the expensive coldchain shipping and storage costs in half. Major benefits were obtained by replacing pre-made plastic trays & lid material with a 100% paperboard material, consisting of a carton and partition. The new package uses a specially designed paper partition that precisely fixes each syringe in a nest. There is no glass-to-glass contact, thus preventing cracks and breakage. The plunger movement is limited by the tight tolerances between the syringe and inner walls of the pack.

5 The cost of distribution

Costs are affected by the volume of the package itself. Where the product must be held in a temperature-controlled environment, it is particularly important to adopt a package of minimum volume relative to its contents. Minimising package volume also benefits storage immediately prior to use; for example in a hospital pharmacy.

The immense cost pressure within the medical sector encourages the increasing trend towards self-medication. The branch of liquid pharmaceuticals is also drawn into this development with the use of prefilled syringes and injection devices on the increase. They are not only easy and safe to handle by the patients themselves, but are also favoured by both doctors and hospitals. The potential dangers involved with breaking the ampoule are therefore avoided. Another important factor for this development is found in the low logistical costs which, thanks to optimal packaging solutions, are easily accomplished.